Eriksen’s goal came just minutes after Maguire’s dismissal for two needless first half bookings and condemned Gareth Southgate’s side to their first defeat in 12 months.
Maguire was the third England player to be sent off at Wembley after Paul Scholes in 1999 and Steven Gerrard in 2012.
And adding to Southgate’s mounting discipline problems, Reece James was shown a red card after confronting the referee following the final whistle.
England came from behind to hand top ranked Belgium their first defeat since 2018 on Sunday, building on last week’s friendly win against Wales.
But Southgate had urged his team to show they can maintain the consistency required of elite teams and this was an underwhelming response.
England are now third in Nations League Group A2, behind both Belgium and Denmark.